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The Role of Calcium alpha-ketoglutarate (Ca-AKG) in enhancing Longevity and anti-aging
Calcium alpha-ketoglutarate (Ca-AKG) is a compound that has garnered attention in the context of longevity and health span due to its involvement in various metabolic processes and potential effects on aging. Here are some of the key roles and mechanisms through which Ca-AKG may influence longevity:
1. Metabolic Regulation: Ca-AKG serves as an intermediate in the Krebs cycle (also known as the citric acid cycle), which is crucial for energy production in cells. By supporting mitochondrial function and enhancing ATP production, Ca-AKG may help maintain cellular energy levels as organisms age.
2. Anti-inflammatory Effects: Aging is often associated with increased chronic inflammation. Some studies suggest that Ca-AKG may have anti-inflammatory properties that could mitigate age-related inflammation, promoting healthier aging.
3. Cellular Senescence: There is evidence that Ca-AKG can influence cellular senescence—the process where cells lose their ability to divide and function properly. By modulating pathways related to senescence, Ca-AKG may potentially help to delay the onset of age-related diseases.
4. Nutrient Sensing and Longevity Pathways: Ca-AKG may interact with various longevity-related pathways, including those involving the sirtuin family of proteins, mTOR signaling, and AMP-activated protein kinase (AMPK). These pathways are critical for regulating metabolism, stress responses, and overall cellular health.
5. Potential Effects on Lifespan: Some animal studies have suggested that supplementation with AKG (the active form of alpha-ketoglutarate) can extend lifespan and promote healthier aging in model organisms. While the exact mechanisms remain under investigation, these findings have sparked interest in its potential applications for human longevity.
6. Supporting Gut Microbiome: Emerging research indicates that Ca-AKG may have beneficial effects on gut health by supporting the growth of beneficial gut bacteria. A healthy gut microbiome is increasingly linked to various aspects of overall health and longevity.
7. Genetic and Epigenetic Regulation: Ca-AKG is thought to participate in various epigenetic processes, such as histone modification, which can influence gene expression related to aging and longevity.
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